Journal of Immunology Research / 2013 / Article / Tab 6

Research Article

Overexpression of HIF-2α, TWIST, and CXCR4 Is Associated with Lymph Node Metastasis in Papillary Thyroid Carcinoma

Table 6

mRNA expression of HIF-2α, TWIST, and CXCR4 in PTCs, nodular hyperplasia, and normal thyroid tissues.

TissueCase ( )HIF-2αTWISTCXCR4
ΔCT, mean ± SD valueΔCT, mean ± SD valueΔCT, mean ± SD value

Normal thyroid tissue10
Nodular hyperplasia10 0.940 0.111 0.226
PTC without LNM15 0.101 <0.001a <0.001a
PTC with LNM15 0.467 0.005b 0.010b

Mean ± SD of HIF-2α, TWIST and CXCR4 mRNA expression in normal thyroid and nodular hyperplasia tissues, PTCs without LNM and PTCs with LNM after normalization to GAPDH (Mann-Whitney test, asignificant difference between PTCs without LNM and normal thyroid tissues; bsignificant difference in HIF-2α, TWIST, and CXCR4 mRNA expression between PTCs with LNM and PTCs without LNM).

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