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Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 617595, 8 pages
Review Article

Thymic Regulatory T Cell Development: Role of Signalling Pathways and Transcription Factors

1Centre for Inflammatory Diseases, Monash Medical Centre, Southern Clinical School, Monash University, Clayton, VIC 3168, Australia
2Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia
3Department of Clinical Haematology, Central Clinical School, Melbourne, VIC 3000, Australia

Received 14 June 2013; Accepted 21 August 2013

Academic Editor: E. Shevach

Copyright © 2013 Mark Engel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Regulatory T cells (Tregs) are a subset of CD4 T cells that are key mediators of immune tolerance. Most Tregs develop in the thymus. In this review we summarise recent findings on the role of diverse signalling pathways and downstream transcription factors in thymic Treg development.