Thymic Regulatory T Cell Development: Role of Signalling Pathways and Transcription Factors
Figure 1
The stages of tTreg development. Thymic Treg development is achieved in two stages. Initially, postpositive selected thymocytes undergo TCR and CD28 dependent maturation into a Foxp tTreg precursor population. A subsequent IL-2 dependent step leads to the development of Foxp3 expressing mature tTregs.
