Interleukin-15 (IL-15) and Anti-C1q Antibodies as Serum Biomarkers for Ectopic Pregnancy and Missed Abortion

Table 2

IL-15 concentrations in 60 women with failed pregnancies, including 30 women with ectopic pregnancy (EP) and missed abortion (MA) and 33 women with intrauterine pregnancy (IUP). Median, interquartile range (IR) in pg/mL, and the Mann-Whitney P value are presented. Additionally sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPP) were calculated and IL-15 values were plotted in ROC curves in order to further evaluate their diagnostic accuracy for the diagnosis of healthy IUP and for accurate discrimination of an EP from a MA. All AUCs are shown.

IL-15; Serum levels	Median (interquartile range); Mann Whitney P	Sensitivity	Specificity	Cut-off point	Direction	AUC	P value; (ROC curve)	PPV	NPV
Failed versus normal	19.86 (16.04–26.97); 15.06 (12.74–21.41); P  <  0.001	0.750	0.682	16.1	Upper	0.725	0.002	0.310	0.935
Abortion versus normal	16.63 (14.56–21.37); 15.06 (12.74–21.41); P < 0.001	0.857	0.364	14.0	Upper	0.605	0.207	0.192	0.935
Ectopic versus normal	24.9 (18.59–29.81); 15.06 (12.74–21.41); P  <  0.001	0.917	0.682	16.1	Upper	0.818	<0.001	0.028	0.999
Ectopic versus abortion	24.9 (18.59–29.81); 16.63 (14.56–21.37); P  =  0.015	0.861	0.571	16.9	Upper	0.753	0.001	0.118	0.984