Targeting BCL2 Family in Human Myeloid Dendritic Cells: A Challenge to Cure Diseases with Chronic Inflammations Associated with Bone Loss

Figure 1

Dendritic cell functions compared to monocytes. Monocyte-derived DCs share four functions with monocytes: phagocytosis, TRAIL synthesis, Ag presentation, and differentiation into OC in the presence of M-CSF and RANKL. Conversely, initiation of tolerance, adaptive response, and IL-17A-dependent differentiation of GMIC are DC-specific functions. IFN-γ differentially regulates MGC formation by inhibiting OC and stimulating GMIC formation.