Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia

Figure 4

Correlation of Tfh cells frequency in BM and clinical evidence in IRP patients. (a) Relationship between the frequency of the BM CD4⁺CXCR5⁺ Tfh cells and the expression of Bcl-6 mRNA in IRP group. (b) Relationship between the frequency of the BM CD4⁺CXCR5⁺ Tfh cells and the ratio of CD19⁺/BMMNC in IRP group. (c) Relationship between the frequency of the BM CD4⁺CXCR5⁺ Tfh cells and the ratio of CD3⁺CD8⁻IL-4⁺/CD3⁺CD8⁻ in IRP group. (d) Relationship between the frequency of the BM CD4⁺CXCR5⁺ Tfh cells and the ratio of CD34⁺IgG⁺/BMMNC in IRP group. (e) Relationship between the frequency of the BM CD4⁺CXCR5⁺ Tfh cells and the total serum IgG level in IRP group. (f) Relationship between the frequency of the BM CD4⁺CXCR5⁺ Tfh cells and the ratio of Th1/Th2 in IRP group. (g) Relationship between the frequency of the BM CD4⁺CXCR5⁺ Tfh cells and the level of serum C3 in IRP group. (h) Scatterplot of the percentage of CD4⁺CXCR5⁺ICOS⁺ cells versus CD4⁺CXCR5⁺CD40L⁺ cells from 90 IRP patients showing a correlation.