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Clinical and Developmental Immunology
Volume 2013, Article ID 730450, 10 pages
http://dx.doi.org/10.1155/2013/730450
Clinical Study

Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia

Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan Street, Heping District, Tianjin 300052, China

Received 23 June 2013; Accepted 22 July 2013

Academic Editor: Dimitrios P. Bogdanos

Copyright © 2013 Hong Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. He, Z. H. Shao, H. Liu et al., “Immune-related pancytopenia,” Chinese Journal of Hematology, vol. 22, pp. 79–82, 2001. View at Google Scholar
  2. Z. H. Shao and R. Fu, “Immuno-related pancytopenia: a newly recognized disease (part 1),” Chinese Journal of Medicine, vol. 40, pp. 5–8, 2005. View at Google Scholar
  3. Z. H. Shao and R. Fu, “Immuno-related pancytopenia: a newly recognized disease (part 2),” Chinese Journal of Medicine, vol. 41, pp. 6–9, 2005. View at Google Scholar
  4. H. He, Z. H. Shao, Z. Cao et al., “Bone marrow mononuclear Coombs test,” Chinese Journal of Hematology, vol. 21, pp. 550–551, 2000. View at Google Scholar
  5. J. Sun, Z. Cao, M. F. Tu et al., “Direct antiglobulin test of bone marrow mononuclear cells: results of 270 cases with autoimmune hemocytopenia,” Chinese Journal of Practical Internal Medicine, vol. 26, no. 1-2, pp. 12–14, 2006. View at Google Scholar
  6. H. He and Z. H. Shao, “Modified direct antiglobulin test,” Chinese Journal of Laboratory Medicine, vol. 24, no. 5, pp. 313–315, 2001. View at Google Scholar
  7. R. Fu, Z.-H. Shao, H. Liu et al., “Category, quantity and clinical significance of autoantibodies on bone marrow hematopoietic cells in patients with immunorelated cytopenia,” Zhonghua Xue Ye Xue Za Zhi, vol. 24, no. 4, pp. 177–180, 2003. View at Google Scholar · View at Scopus
  8. Y.-H. Wang, R. Fu, Z.-H. Shao et al., “[Study on quantity and function of bone marrow macrophages in patients with BMMNC-Coombs Test(+) pancytopenia],” Zhonghua Xue Ye Xue Za Zhi, vol. 30, no. 8, pp. 538–542, 2009. View at Google Scholar · View at Scopus
  9. J. Chen, R. Fu, L.-J. Li et al., “Variation in complement level and its significance in cytopenia patients with positive BMMNC-Coombs,” Zhonghua Xue Ye Xue Za Zhi, vol. 30, no. 7, pp. 454–457, 2009. View at Google Scholar · View at Scopus
  10. H. Liu, R. Fu, L. J. Li et al., “Preliminary study of the relationship between EPO receptor and autoantibody on the membrane of erythropoietic cells of the patients with BMMNC-Coomb’s test(+) hemocytopenia,” Zhonghua Xue Ye Xue Za Zhi, vol. 31, no. 6, pp. 413–415, 2010. View at Google Scholar
  11. R. Fu, Z. Shao, H. He et al., “Quantity and apoptosis-related protein level of B lymphocyte in patients with immunorelated pancytopenia,” Zhonghua Xue Ye Xue Za Zhi, vol. 23, no. 5, pp. 236–238, 2002. View at Google Scholar · View at Scopus
  12. R. Fu, J. Chen, H.-L. Wang et al., “Quantity and function of regulatory T cells in hemocytopenic patients with positive BMMNC-Coombs test,” Zhonghua Yi Xue Za Zhi, vol. 90, no. 42, pp. 2989–2993, 2010. View at Google Scholar · View at Scopus
  13. R. Fu, Z.-H. Shao, H. Liu et al., “Proliferation of bone marrow hematopoietic stem cells and function of T helper lymphocytes of patients with immuno-related pancytopenia,” Zhonghua Xue Ye Xue za Zhi, vol. 25, no. 4, pp. 213–216, 2004. View at Google Scholar · View at Scopus
  14. R. Fu, H. L. Wang, J. Chen et al., “Study of the quantity and function of Th17 cells in the blood cytopenic patients with positive BMMNC-Coombs test,” Zhonghua Xue Ye Xue Za Zhi, vol. 31, no. 10, pp. 684–687, 2010. View at Google Scholar
  15. Z. H. Shao and R. Fu, “Research study of diagnosis and treatment of Immuno-related pancytopenia,” Chinese Journal of Practical Internal Medicine, vol. 26, no. 7, pp. 481–483, 2006. View at Google Scholar
  16. R. Fu, “Diagnosis and treatment of Immuno-related pancytopenia,” Chinese Journal of Practical Internal Medicine, vol. 26, no. 7, pp. 492–496, 2006. View at Google Scholar
  17. C. King, S. G. Tangye, and C. R. Mackay, “T follicular helper (TFH) cells in normal and dysregulated immune responses,” Annual Review of Immunology, vol. 26, pp. 741–766, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. C. King, “A fine romance: T follicular helper cells and B cells,” Immunity, vol. 34, no. 6, pp. 827–829, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Aoki, M. Kido, S. Iwamoto et al., “Dysregulated generation of follicular helper T cells in the spleen triggers fatal autoimmune hepatitis in mice,” Gastroenterology, vol. 140, no. 4, pp. 1322–1333, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. J. E. Craft, “Follicular helper T cells in immunity and systemic autoimmunity,” Nature Reviews Rheumatology, vol. 8, no. 6, pp. 337–347, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. H. He, Z. H. Shao, and R. Fu, “Hemocytopenia related to immunity detected by modified Coombs test for measuring autoantibody of bone marrow mononuclear cells,” Blood, vol. 100, article 136b, 2002. View at Google Scholar
  22. H. Liu, R. Fu, Y. H. Wang et al., “Detection and analysis of autoantigens targeted by autoantibodies in immunorelated pancytopenia,” Clinical and Developmental Immunology, vol. 2013, Article ID 297678, 7 pages, 2013. View at Publisher · View at Google Scholar
  23. M. Goto, K. Kuribayashi, Y. Takahashi et al., “Identification of autoantibodies expressed in acquired aplastic anaemia,” British Journal of Haematology, vol. 160, pp. 359–362, 2013. View at Google Scholar
  24. C. S. Ma, E. K. Deenick, M. Batten et al., “The origins, function, and regulation of T follicular helper cells,” The Journal of Experimental Medicine, vol. 209, no. 7, pp. 1241–1253, 2012. View at Google Scholar
  25. C. G. Vinuesa, M. C. Cook, C. Angelucci et al., “A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity,” Nature, vol. 435, no. 7041, pp. 452–458, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. M. A. Linterman, R. J. Rigby, R. K. Wong et al., “Follicular helper T cells are required for systemic autoimmunity,” Journal of Experimental Medicine, vol. 206, no. 3, pp. 561–576, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. N. Simpson, P. A. Gatenby, A. Wilson et al., “Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus,” Arthritis and Rheumatism, vol. 62, no. 1, pp. 234–244, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. R. Morita, N. Schmitt, S.-E. Bentebibel et al., “Human blood CXCR5+CD4+ T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion,” Immunity, vol. 34, no. 1, pp. 108–121, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Ma, C. Zhu, B. Ma et al., “Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis,” Clinical and Developmental Immunology, vol. 2012, Article ID 827480, 7 pages, 2012. View at Publisher · View at Google Scholar
  30. C. Zhu, M. Jie, Y. Liu et al., “Increased frequency of follicular helper T cells in patients with autoimmune thyroid disease,” Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 3, pp. 943–950, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Zaidan, P. Cervera-Pierot, S. de Seigneux et al., “Evidence of follicular T-cell implication in a case of IgG4-related systemic disease with interstitial nephritis,” Nephrology Dialysis Transplantation, vol. 26, no. 6, pp. 2047–2050, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. C. S. Ma, D. T. Avery, A. Chan et al., “Functional STAT3 deficiency compromises the generation of human T follicular helper cells,” Blood, vol. 119, no. 17, pp. 3997–4008, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. S. Choi, R. Kageyama, D. Eto et al., “ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6,” Immunity, vol. 34, no. 6, pp. 932–946, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. L. Bossaller, J. Burger, R. Draeger et al., “ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th Cells,” Journal of Immunology, vol. 177, no. 7, pp. 4927–4932, 2006. View at Google Scholar · View at Scopus
  35. A. Vogelzang, H. M. McGuire, D. Yu, J. Sprent, C. R. Mackay, and C. King, “A fundamental role for interleukin-21 in the generation of T follicular helper cells,” Immunity, vol. 29, no. 1, pp. 127–137, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. K. Lüthje, A. Kallies, Y. Shimohakamada et al., “The development and fate of follicular helper T cells defined by an IL-21 reporter mouse,” Nature Immunology, vol. 13, no. 5, pp. 491–498, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. R. J. Johnston, A. C. Poholek, D. DiToro et al., “Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation,” Science, vol. 325, no. 5943, pp. 1006–1010, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. D. Yu, S. Rao, L. M. Tsai et al., “The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment,” Immunity, vol. 31, no. 3, pp. 457–468, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. M. A. Kroenke, D. Eto, M. Locci et al., “Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation,” Journal of Immunology, vol. 188, no. 8, pp. 3734–3744, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. R. I. Nurieva, Y. Chung, G. J. Martinez et al., “Bcl6 mediates the development of T follicular helper cells,” Science, vol. 325, no. 5943, pp. 1001–1005, 2009. View at Publisher · View at Google Scholar · View at Scopus