Figure 2: Forskolin and isoproterenol elevated cAMP production compared with untreated spleen cells in vitro in saline-treated non-AA rats. In contrast, forskolin, but not isoproterenol treatment, increased cAMP production compared with untreated splenocytes in AA rats. The lower cAMP production observed in splenocytes treated with isoproterenol in AA rats was also significantly different compared with non-AA rats. Data are expressed as a mean ± SEM with an of 8 rats per treatment group. Statistics: one-way ANOVA with Bonferroni multiple comparison tests (* ).