Therapeutic Potential of Tolerogenic Dendritic Cells in IBD: From Animal Models to Clinical Application

Figure 2

General scheme: dendritic cell therapy for Crohn’s disease patients. Isolated monocytes are cultured and differentiated into DCs by adding IL-4 and GM-CSF to the media. At day 3, addition of dexamethasone induces the tolerogenic profile, and at day 6, addition of the maturation cytokine cocktail potentiates the tolerogenic properties.