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Clinical and Developmental Immunology
Volume 2013, Article ID 818654, 4 pages
Clinical Study

Clinical Characteristics of Nocardia Infection in Patients with Rheumatic Diseases

Department of Allergy and Clinical Immunology, Chiba University Hospital, 1-8-1 Inohana, Chiba, Chiba City 260-8677, Japan

Received 4 July 2013; Accepted 26 August 2013

Academic Editor: T. Nakayama

Copyright © 2013 Mieko Yamagata et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although Nocardiosis has considerable recurrence and mortality rates, characteristics and risk factors of Nocardia infection have not been assessed in patients with rheumatic diseases. Here, we examined the characteristics and risk factors of Nocardia infection in rheumatic disease patients in our hospital. Ten rheumatic disease patients who developed Nocardia infection were identified by retrospectively reviewing the medical records. Possible predisposing factors for Nocardia infection were high-dose glucocorticoid treatment, concomitant use of immunosuppressants, preexisting pulmonary diseases, and diabetes mellitus. All patients had pulmonary Nocardiosis, and six of them had disseminated Nocardiosis when their pulmonary lesions were identified.