Chimerism-Based Experimental Models for Tolerance Induction in Vascularized Composite Allografts: Cleveland Clinic Research Experience
Figure 2
(a) Interaction of memory T cells and antigen pretention cells (APCs) without immunosuppression induced T-cell response and allograft rejection. (b) Selective targeting of α β-TCR of TCR/CD3 complex inhibits the first signal of T-cell activation. Inhibition of immune response is enhanced by CsA, which inhibits IL-2 production by T cells and reduces expression of costimulatory molecules of dendritic cells. Lack of immune response by T cells facilitates allograft acceptance.
