Review Article

New Insights on Human Polyomavirus JC and Pathogenesis of Progressive Multifocal Leukoencephalopathy

Figure 1

JCV noncoding control regions (NCCRs) containing cellular transcription factor-binding sites of archetype variant CY (a), commonly found in urine of healthy individuals and Mad-1 (b), Mad-4 (c), and Mad-8 (d) NCCR variants, illustrative of the major NCCR arrangements found in PML tissue.
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(a) Archetype
839719.fig.001b
(b) Mad-1
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(c) Mad-4
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(d) Mad-8