P53 and Expression of Immunological Markers May Identify Early Stage Thyroid Tumors

Table 1

Immunohistochemical (IHC) expression of p53 protein using automated cellular imaging system ACIS-III quantitative analysis, according to histopathological diagnosis.

	Histopathology	Total number of patients	IHQ quantitative analysis in the; whole group		Number of patients positive for p53	IHQ quantitative analysis for; positive cases
			Mean value	Median value		Mean value	Median value
Benign lesions	Normal thyroid tissue	16	1.76	1.11	0	—	—
	Nodular goiter	50	4.82	1.71	8	17.25	15.52
	Follicular adenoma	55	8.75	3.68	19	20.47	15.72
	Papillary thyroid carcinoma	164	51.85	53.59	127	52.32	63.69
Malignant lesions	Classic	106	42.16	32.24	83	62.17	70.70
	Follicular variant	54	38.15	39.18	41	54.30	57.92
	Tall cell variant	04			03	49.31	55.08
	Follicular carcinoma	42	11.11	2.17	11	36.36	21.64