Regulatory T Cells in the Immunodiagnosis and Outcome of Kidney Allograft Rejection

Table 1

Characteristics of the described studies.

Study	Type of patient	Patients* (𝑛^∘)	Treg identification	Treg or Foxp3 expression	Characteristic
Muthukumar et al. (2005) [34]	KT with AR	36	Foxp3 mRNA in urine	Elevated	Survival rate graft
Veronese et al. (2007) [35]	KT with AR	59	Foxp3 CD4^+ in kt	Elevated	Survival rate graft
Bunnag et al. (2008) [36]	KT with AR	31	Foxp3 mRNA in kt	Elevated	Survival rate graft
Aquino-Dias et al. (2008) [37]	KT with AR	20	Foxp3 mRNA in kt,; PBL, urine	Elevated	Diagnosis of AR
Mansour et al. (2008) [38]	KT with BL changes	46	Foxp3 mRNA in kt	Reduced in PG	Outcome of BL changes
Xu et al. (2012) [39]	KT	125	Foxp3-positive T lymphocytes in kt	Elevated in RPG	Outcome of graft
Chung et al. (2012) [40]	KT with AR	56	Foxp3/IL-17 secreting cells ratio in kt	Elevated (in SRGa)	Survival rate graft
San Segundo et al. (2012) [41]	KT	90	Foxp3 CD4^+ CD25^+ in PBL	Elevated (in SRGa)	Survival rate graft

∗The number of patients does not refer to the total number of patients in each study, but to the subpopulation considered.
KT: kidney transplantation; AR: acute rejection; kt: kidney tissue; PBL: peripheral blood lymphocytes; BL changes: borderline changes; PG: progressive group; RPG: regulatory phenotype group; SRGa: patients with augmented survival rate graft.