Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection

Table 1

Demographic and clinical characteristics of 171 male HCC patients.

	Number of cases	Percentage
Age of onset^†
Median (IQR)^‡	50 (42~57)	—
Range	24~74	—
Cirrhosis	142	83.0.%
TNM stage III or IV	63	36.8%
HBsAg positive	171	100%
HBeAg positive	60	35.1%
HBV DNA copy number†§
Mean	2.3𝐸+06	—
Range	0~4.8𝐸+07	—
Family history of HCC	9	5.3%
Family history of HBV-related diseases¶	43	25.1%
Alcohol consumption (≥1 drink per week)	20	11.7%

†Age of first diagnosis for HCC.
^‡Age is presented as median, interquartile range (IQR), which are determined by KM estimates.
§70 patients were quantified for HBV DNA when they were diagnosed as HCC.
¶HBV-related diseases include HBV-related hepatitis, cirrhosis, liver failure, and HCC.