Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection

Table 3

Effects of HLA-C-KIR ligand-receptor combinations on the onset age of HCC by KM analysis.

HLA-KIR combination		𝑛	Median age	P value
C1C1-KIR2DL3	Negative	40	50	0.81
	Positive	98	47
C1C2-KIR2DL3	Negative	109	48	0.78
	Positive	29	50
C1C2-KIR2DL1	Negative	110	49	0.65
	Positive	28	50
C2C2-KIR2DL1	Negative	131	49	0.81
	Positive	7	50
C1C1-KIR2DS2/2DL2	Negative	141	50	0.004**
	Positive	20	44
C1C2-KIR2DS2/2DL2	Negative	155	49	0.53
	Positive	8	53
C1C2-KIR2DS1	Negative	134	50	0.68
	Positive	7	50
C2C2-KIR2DS1	Negative	138	50	0.12
	Positive	3	43

^∗∗𝑃<0.01.