Different Peripheral Tissue Injury Induces Differential Phenotypic Changes of Spinal Activated Microglia
Figure 1
OX-42 and Iba-1 immunoreactivity in the spinal cord dorsal horn after different treatment to rats. A significant increase of OX-42 and Iba-1 expression was present following CCI injury and formalin injection, which was accompanied with obvious morphological change compared with naïve group ((a); Scale bar, 200 μm). The magnified images in yellow box showed the morphology of a single-activated microglia. Representative bands and quantification of western blot analysis (b) showed increased Iba-1 protein level in the lumbar spinal cord after CCI injury and formalin injection, not after CFA injection. *, one-way ANOVA and Tukey post hoc test, compared with the naïve (no treatment) control, .
