Journal of Immunology Research / 2013 / Article / Fig 3

Research Article

An Attenuated Cytomegalovirus Vaccine with a Deletion of a Viral Chemokine Gene Is Protective against Congenital CMV Transmission in a Guinea Pig Model

Figure 3

The v545 virus is attenuated in strain 2 guinea pigs. (a) Weight loss and DNAemia profiles were compared following inoculation of young, nonpregnant guinea pigs with v545 and control vAM403 virus. Animals inoculated with v545 gained weight throughout this postinoculation time period (mean weight gain at day 9, 40 grams) compared to animals infected with vAM403 (weight loss of 5 grams; ). (b) Animals challenged with v545 virus demonstrated reduced DNAemia measured at day 10 (mean viral load, 2.5 log10 genomes/mL versus 3.0 log10 genomes/mL in vAM403 group; ).

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