An Imbalance between Frequency of CD4+CD25+FOXP3+ Regulatory T Cells and CCR4+ and CCR9+ Circulating Helper T Cells Is Associated with Active Perennial Allergic Conjunctivitis

Table 2

Frequencies of cell-subsets and cell-migration receptors after Der 𝑝-stimulation.

Cell-subsets	RPMI; MD (IQR-Range)	Der p; MD (IQR-Range)	Con A mitogen; MD (IQR-Range)	𝑃
				RPMI versus Der p	Der p versus Con A
CD25+	12.5% (10.9–15.7)	20.4% (16.0–26.4)	87.5% (78.2–93.4)	0.001	<0.0001
CD4+CD25+	16.2% (12.5–20.8)	28.2% (23–32.7)	99.4% (99–99.5)	0.0004	<0.0001
CD4+CD25+; F0XP3+	3.5% (1.8–14.9)	57% (50–63.5)	18% (12.8–28.4)	<0.0001	<0.0001
CCR4+	19% (13.2–28)	21% (16–27.6)	69% (56.6–80.2)	0.312	0.002
CCR7+	55% (41.5–63.5)	49% (36–56.9)	84% (72.1–88.2)	0.687	0.0006
CCR7−	45% (36.5–58.5)	51% (43.1–64)	16% (11.8–27.9)	0.687	0.0006
CCR9+	1% (0.5–2.2)	2% (1.9–9.9)	3.4% (2.9–7.6)	0.04	0.62
CD4+CCR4+	32% (21.6–50.7)	32% (24.8–45.3)	91% (84.7–97.5)	0.62	0.001
CD4+CCR7+	86% (79.7–89.1)	82% (74.2–86.9)	98% (95.0–98.5)	0.06	0.0006
CD4+CCR7−	14% (10.9–20.3)	18% (13.1–25.8)	2% (1.5–5.0)	0.06	0.0006
CD4+CCR9+	1% (0.6–3.4)	4% (2.5–19.5)	3.7% (2.9–6.6)	0.15	0.62
CD4+CCR4+; CCR9+	5.2% (2.5–5.5)	13% (10–42.7)	6% (5.4–9.8)	0.01	0.01
CD103+	4% (2.6–7.5)	6% (4.0–7.1)	33% (26.0–34.2)	0.295	0.001
CD108+	9% (30–14.4)	23% (15.6–35.5)	76% (63.8–76.7)	0.01	0.0003
CD4+CD103+	2% (0.9–2.8)	7% (3.3–11.0)	38% (13.8–57.2)	0.007	0.001
CD4+CD108+	6% (1.3–7.6)	27% (14.5–29.9)	76% (69.7–84.8)	0.01	0.002

MD: Median; IQR: Interquartile range.