Journal of Immunology Research / 2013 / Article / Tab 2

Research Article

An Imbalance between Frequency of CD4+CD25+FOXP3+ Regulatory T Cells and CCR4+ and CCR9+ Circulating Helper T Cells Is Associated with Active Perennial Allergic Conjunctivitis

Table 2

Frequencies of cell-subsets and cell-migration receptors after Der -stimulation.

Cell-subsets RPMI
MD (IQR-Range)
Der p
MD (IQR-Range)
Con A mitogen
MD (IQR-Range)
RPMI versus Der p Der p versus Con A

CD25+12.5% (10.9–15.7)20.4% (16.0–26.4)87.5% (78.2–93.4)0.001<0.0001
CD4+CD25+16.2% (12.5–20.8)28.2% (23–32.7)99.4% (99–99.5)0.0004<0.0001
CD4+CD25+
F0XP3+
3.5% (1.8–14.9)57% (50–63.5)18% (12.8–28.4)<0.0001<0.0001
CCR4+19% (13.2–28)21% (16–27.6)69% (56.6–80.2)0.3120.002
CCR7+55% (41.5–63.5)49% (36–56.9)84% (72.1–88.2)0.6870.0006
CCR7−45% (36.5–58.5)51% (43.1–64)16% (11.8–27.9)0.6870.0006
CCR9+1% (0.5–2.2)2% (1.9–9.9)3.4% (2.9–7.6)0.040.62
CD4+CCR4+32% (21.6–50.7)32% (24.8–45.3)91% (84.7–97.5)0.620.001
CD4+CCR7+86% (79.7–89.1)82% (74.2–86.9)98% (95.0–98.5)0.060.0006
CD4+CCR7−14% (10.9–20.3)18% (13.1–25.8)2% (1.5–5.0)0.060.0006
CD4+CCR9+1% (0.6–3.4)4% (2.5–19.5)3.7% (2.9–6.6)0.150.62
CD4+CCR4+
CCR9+
5.2% (2.5–5.5)13% (10–42.7)6% (5.4–9.8)0.010.01
CD103+4% (2.6–7.5)6% (4.0–7.1)33% (26.0–34.2)0.2950.001
CD108+9% (30–14.4)23% (15.6–35.5)76% (63.8–76.7)0.010.0003
CD4+CD103+2% (0.9–2.8)7% (3.3–11.0)38% (13.8–57.2)0.0070.001
CD4+CD108+6% (1.3–7.6)27% (14.5–29.9)76% (69.7–84.8)0.010.002

MD: Median; IQR: Interquartile range.

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