Clinical Study
The Association of CD81 Polymorphisms with Alloimmunization in Sickle Cell Disease
Table 4
SNP genotype association with alloimmunization in SCD.
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Patient numbers are displayed in the order shown in the column labeled genotypes. Relative distribution of genotypes in Sub-Saharan population, as reported by the HapMap. This research utilizes the NCBI SNP database [41], (http://www.ncbi.nih.gov/snp/). The Single Nucleotide Polymorphism database (dbSNP) is a public domain archive for a broad collection of simple genetic polymorphisms. dbSNP reports many cases of SNPs genotyped by HapMap and other projects which provide additional genotype and allele frequency information. NCBI database describes two additional alleles, A/G with very low frequencies (<0.5%) for rs708564. This might be due to a mutational mechanism that leads to the simultaneous creation of two new base pairs at the same site which is beyond the scope of this study [42]. Our results, however, are based on the two reference SNPs alleles (C/T) of rs708564. values significant comparing SCD patients with and without alloimmunization. |