The Association of CD81 Polymorphisms with Alloimmunization in Sickle Cell Disease

Table 5

Hb𝛽^𝑆 genotypes in SCD patients with or without antibodies or with “informative” SNP genotypes.

Hb𝛽^𝑆 haplotype	Total patients	Antibody positive		Antibody negative		𝑃 value
		At least one C/C genotype*	No C/C genotypes*	At least one C/C genotype*	No C/C genotypes*
Bantu/Bantu	15	2	6	7	0	0.0069
Benin/Benin	28	1	10	12	5	0.0021
Other**	33	3	13	11	5	0.0113
Total	75	6	29	30	10	6.17 × 10^−7

∗Patients were divided into groups that had rs708564C/C and/or rs22378563C/C genotypes (group one) or were double negative for these genotypes (group two).
∗∗Includes any haplotypes found in 10 or less subjects (Senegal/Senegal; Benin/Cameroon; Senegal/Benin; Cameroon/Cameroon; Benin/Bantu; Bantu/Cameroon; Senegal/Cameroon; Benin/𝛽thal; and Senegal/𝛽thal).