N-Terminal Plasmodium vivax Merozoite Surface Protein-1, a Potential Subunit for Malaria Vivax Vaccine
Figure 1
Schematic representation of the protein PvMSP1 according to two classifications adapted from Bastos et al. [38]. (a) Diagram showing the division of PvMSP-1 into interspecies conserved blocks (ICBs) among P. falciparum, P. vivax, and P. yoelii (blank), blocks conserved between P. falciparum and P. vivax (in gray), and polymorphic blocks (black), by Del Portillo et al. [39]. Another scheme showing the division of PvMSP-1 in 13 blocks, 7 conserved blocks (blank), and six polymorphic blocks (black) by Putaporntip et al. [40]. (b) Location and amine acids sequences of three recombinant proteins correspondent to Block-2 variants of PvMSP-1; (P1) conserved region located upstream of Block2; (P2) corresponding to the repeats of haplotype belem; and (P3) corresponding to the repeats of another haplotype of Pv-MSP1 Block 2 circulating in Manaus [41].
