T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis

Figure 4

TCV influenced the expressions of Th1/Th17/Tfh related transcriptional factors in CIA mice. Purified CD4+ T cells from splenocytes were prepared and analyzed for the mRNA expressions of T-bet, RORα, RORγt and Bcl6 by real-time RT-PCR. Data are presented as means ± SE. Data are represented as means ± SD (𝑛=10 mice/group). Data are representative of 5 separate experiments with similar results. *𝑃<0.05, **𝑃<0.01, CIA versus normal group. ^#𝑃<0.05, TCV versus normal group. ^$𝑃<0.05, TCV versus CIA group.