T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis
TCV influenced the expressions of Th1/Th17/Tfh related transcriptional factors in CIA mice. Purified CD4+ T cells from splenocytes were prepared and analyzed for the mRNA expressions of T-bet, RORα, RORγt and Bcl6 by real-time RT-PCR. Data are presented as means ± SE. Data are represented as means ± SD ( mice/group). Data are representative of 5 separate experiments with similar results. *, **, CIA versus normal group. #, TCV versus normal group. , TCV versus CIA group.
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