JC Polyomavirus (JCV) and Monoclonal Antibodies: Friends or Potential Foes?

Figure 3

Mechanisms of PML pathogenesis. The necessary condition for the PML developments is that oligodendrocytes are infected by JCV. In this figure the three ways through which the virus could cross the BBB are represented: (a) as free virus or (b) the infection of the endothelial cells of the barrier by JCV-infected B cells (c) using the B cells as “a Trojan horse.”