Review Article
JC Polyomavirus (JCV) and Monoclonal Antibodies: Friends or Potential Foes?
Table 1
Nonstructural and structural viral protein.
| Protein | Molecular weight |
No. of amino acids | Function |
| Early protein (transcribed counterclockwise from NCCR) | Large T antigen | 79,305 | 688 | Nonstructural protein. role in viral replication and transcription, interaction with host protein and probably in cancerogenesis | Small t antigen | 20,236 | 172 | Viral replication | Splice variants called , , and | | | Viral DNA and cancerogenesis |
| Late protein (transcribed clockwise from NCCR) | VP1 | 39,606 | 354 | Major capsid protein, role in cellular binding and entry functions, and interaction with host receptors; it mediates hemagglutination | VP2 | 37,366 | 344 | Minor capsid protein, assumed role on escape from membranous structures and nuclear import | VP3 | 25,743 | 225 | Minor capsid protein assumed role on escape from membranous structures and nuclear import | Agnoprotein | 8,081 | 71 | The smaller protein that facilities capsid assembly. It is proposed as a viroporin |
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