Research Article
Highlights on Novel Technologies for the Detection of Antibodies to Ro60, Ro52, and SS-B
Table 1
Sensitivities and specificities of the different assays in different diseases.
| | | QUANTA Flash Ro52 | BioPlex 2200
Ro52 | QUANTA Flash
Ro60 | BioPlex 2200
Ro60 | QUANTA Flash
SS-B | BioPlex 2200
SS-B |
| | Antigen source | Recombinant, insect cells | Recombinant, insect cells | Recombinant, insect cells | Native | Recombinant, insect cells | Native | | Analytical measuring range (cut-off) | 2.3–1685.3 CU (20 CU) | 0.2–8.0 units (1.0 units) | 4.9–1374.8 CU (20 CU) | 0.2–8.0 units (1.0 units) | 3.3–1706.8 CU (20 CU) | 0.2–8.0 units (1.0 units) | | Sensitivity in SARD % (95% CI) | 47.2 (37.5–57.1) | 40.7 (31.4–50.6) | 65.7 (56.0–74.6) | 68.5 (58.9–77.1) | 24.1 (16.4–33.3) | 33.3 (24.6–43.1) | | Sensitivity in SLE % (95% CI) | 50.0 (28.2–71.8) | 45.5 (24.4–67.8) | 68.2 (45.1–86.1) | 68.2 (45.1–86.1) | 31.8 (13.9–54.9) | 45.5 (24.4–67.8) | | Sensitivity in SjS % (95% CI) | 51.9 (37.8–65.7) | 44.4 (30.9–58.6) | 75.9 (62.4–86.5) | 75.9 (62.4–86.5) | 31.5 (19.5–45.6) | 31.5 (19.5–45.6) | | Specificity % (95% CI) | 92.5 (86.6–96.3) | 95.5 (90.4–98.3) | 93.2 (87.5–96.9) | 93.2 (87.5–96.9) | 97.7 (93.5–99.5) | 94.7 (89.5–97.9) |
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