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Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 986789, 16 pages
Review Article

Th17 Cells in Immunity and Autoimmunity

Department of Microbiology and Cell Science, University of Florida, P.O. Box 110700, Museum Road Building 981, Gainesville, FL 32611, USA

Received 3 September 2013; Revised 13 November 2013; Accepted 20 November 2013

Academic Editor: Luca Gattinoni

Copyright © 2013 Simone Kennedy Bedoya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Th17 and IL-17 play important roles in the clearance of extracellular bacterial and fungal infections. However, strong evidence also implicates the Th17 lineage in several autoimmune disorders including multiple sclerosis, psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. The Th17 subset has also been connected with type I diabetes, although whether it plays a role in the pathogenicity of or protection from the disease remains a controversial issue. In this review we have provided a comprehensive overview of Th17 pathogenicity and function, including novel evidence for a protective role of Th17 cells in conjunction with the microbiota gut flora in T1D onset and progression.