Proinflammatory Effects of Diesel Exhaust Nanoparticles on Scleroderma Skin Cells

Figure 4

Real time PCR analysis of the expression of MMP-2, MMP-3, MMP-7, MMP-9, and MMP-12, Col I and Col III, and VEGF in primary culture of fibroblasts from sclerodermic and healthy subjects (^∗𝑃<0.01; ^#𝑃<0.001) (a). Real time PCR analysis of the expression of MMP-2 (b), MMP-7 (c), and MMP-9 (d) in primary culture of fibroblasts from sclerodermic and healthy subjects stimulated with Euro 4 and Euro 5 nanoparticles (30 and 60 μg/mL) for 6 h. (^∗𝑃<0.01 versus control; °𝑃<0.01 versus healthy subjects).

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