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Journal of Immunology Research
Volume 2014, Article ID 138751, 9 pages
http://dx.doi.org/10.1155/2014/138751
Research Article

Proinflammatory Effects of Diesel Exhaust Nanoparticles on Scleroderma Skin Cells

1Laboratorio di Fisiopatologia Cutanea, Istituto Dermatologico S Gallicano, Via E. Chianesi 53, 00144 Roma, Italy
2Istituto di Ricerche sulla Combustione (IRC), CNR, Piazzale V. Tecchio 80, 80125 Napoli, Italy
3Dipartimento di Medicina Clinica, Università Sapienza, CNR, Viale dell'Università 37, 00185 Roma, Italy
4Istituto Motori (IM), Via Marconi 8, 80125 Napoli, Italy
5Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China

Received 20 February 2014; Accepted 9 May 2014; Published 1 June 2014

Academic Editor: Takemi Otsuki

Copyright © 2014 A. Mastrofrancesco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. W. Miller, K. M. Pollard, C. G. Parks et al., “Criteria for environmentally associated autoimmune diseases,” Journal of Autoimmunity, vol. 39, no. 4, pp. 253–258, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. C. Selmi, Q. Lu, and M. C. Humble, “Heritability versus the role of the environment in autoimmunity,” Journal of Autoimmunity, vol. 39, no. 4, pp. 249–252, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. G. F. Mora, “Systemic sclerosis: environmental factors,” The Journal of Rheumatology, vol. 36, no. 11, pp. 2383–2396, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. B. M. Javierre, H. Hernando, and E. Ballestar, “Environmental triggers and epigenetic deregulation in autoimmune disease,” Discovery Medicine, vol. 12, no. 67, pp. 535–545, 2011. View at Google Scholar · View at Scopus
  5. K. H. Costenbader, S. Gay, M. E. Alarcón-Riquelme, L. Iaccarino, and A. Doria, “Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases?” Autoimmunity Reviews, vol. 11, no. 8, pp. 604–609, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Varga and D. Abraham, “Systemic sclerosis: a prototypic multisystem fibrotic disorder,” Journal of Clinical Investigation, vol. 117, no. 3, pp. 557–567, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Gabrielli, E. V. Avvedimento, and T. Krieg, “Mechanisms of disease: scleroderma,” The New England Journal of Medicine, vol. 360, no. 19, pp. 1989–2003, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Gilliam, “Scleroderma,” Current Directions in Autoimmunity, vol. 10, pp. 258–279, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. S. B. Randone, S. Guiducci, and M. M. Cerinic, “Systemic sclerosis and infections,” Autoimmunity Reviews, vol. 8, no. 1, pp. 36–40, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Selmi, P. S. C. Leung, D. H. Sherr et al., “Mechanisms of environmental influence on human autoimmunity: a national institute of environmental health sciences expert panel workshop,” Journal of Autoimmunity, vol. 39, no. 4, pp. 272–284, 2012. View at Publisher · View at Google Scholar
  11. P. Dospinescu, G. T. Jones, and N. Basu, “Environmental risk factors in systemic sclerosis,” Current Opinion in Rheumatology, vol. 25, no. 2, pp. 179–183, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. I. Marie, J. F. Gehanno, M. Bubenheim et al., “Prospective study to evaluate the association between systemic sclerosis and occupational exposure and review of the literature,” Autoimmunity Reviews, vol. 13, no. 14, pp. 151–156, 2014. View at Publisher · View at Google Scholar
  13. K. Donaldson, L. Tran, L. A. Jimenez et al., “Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure,” Particle and Fibre Toxicology, vol. 2, article 10, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Nel, “Air pollution-related illness: effects of particles,” Science, vol. 308, no. 5723, pp. 804–806, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Nemmar, S. Al-Maskari, B. H. Ali, and I. S. Al-Amri, “Cardiovascular and lung inflammatory effects induced by systemically administered diesel exhaust particles in rats,” The American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 292, no. 3, pp. L664–L670, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Beelen, G. Hoek, P. A. van den Brandt et al., “Long-term exposure to traffic-related air pollution and lung cancer risk,” Epidemiology, vol. 19, no. 5, pp. 702–710, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. B. Frank, M. E. Schuster, R. Schlögl, and D. S. Su, “Emission of highly activated soot particulate—the other side of the coin with modern diesel engines,” Angewandte Chemie—International Edition, vol. 52, no. 10, pp. 2673–2677, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. B. Frank, R. Schlögl, and D. S. Su, “Diesel soot toxification,” Environmental Science and Technology, vol. 47, no. 7, pp. 3026–3027, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. T. G. M. Smijs and J. A. Bouwstra, “Focus on skin as a possible port of entry for solid nanoparticles and the toxicological impact,” Journal of Biomedical Nanotechnology, vol. 6, no. 5, pp. 469–484, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Vierkötter and J. Krutmann, “Environmental influences on skin aging and ethnic-specific manifestations,” Dermato-Endocrinology, vol. 4, no. 3, pp. 227–231, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. A. T. Slominski, M. A. Zmijewski, C. Skobowiat, B. Zbytek, R. M. Slominski, and J. D. Steketee, “Sensing the environment: regulation of localand global homeostasis by the skin's neuroendocrine system,” Advances in Anatomy Embryology and Cell Biology, vol. 212, p. 115, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. S. S. Dang, A. Serafino, J. Müller, R. E. Jentoft, R. Schlögl, and S. Fiorito, “Cytotoxicity and inflammatory potential of soot particles of low-emission diesel engines,” Environmental Science and Technology, vol. 42, no. 5, pp. 1761–1765, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Fiorito, A. Mastrofrancesco, G. Cardinali et al., “Effects of carbonaceous nanoparticles from low-emission and older diesel engines on human skin cells,” Carbon, vol. 49, no. 15, pp. 5038–5048, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. J. E. Martin, S. Assassi, L. M. Diaz-Gallo et al., “A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci,” Human Molecular Genetics, vol. 22, no. 19, pp. 4021–4029, 2013. View at Publisher · View at Google Scholar
  25. G. Di Blasio, C. Beatrice, and S. Molina, “Effect of port injected ethanol on combustion characteristics in a dual-fuel light duty diesel engine,” SAE Technical Paper Series 2013-01-1692, Society of Automotive Engineers, 2013. View at Google Scholar
  26. J. O. Müller, D. S. Su, U. Wild, and R. Schlögl, “Bulk and surface structural investigations of diesel engine soot and carbon black,” Physical Chemistry Chemical Physics, vol. 9, no. 30, pp. 4018–4025, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. E. C. LeRoy, C. Black, R. Fleischmajer et al., “Scleroderma (systemic sclerosis): classification, subsets and pathogenesis,” The Journal of Rheumatology, vol. 15, no. 2, pp. 202–205, 1988. View at Google Scholar · View at Scopus
  28. F. van den Hoogen, D. Khanna, J. Fransen et al., “2013 Classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative,” Arthritis and Rheumatology, vol. 65, no. 11, pp. 2737–2747, 2013. View at Publisher · View at Google Scholar
  29. D. Kovacs, E. Flori, V. Maresca et al., “The eumelanin intermediate 5,6-dihydroxyindole-2-carboxylic acid is a messenger in the cross-talk among epidermal cells,” Journal of Investigative Dermatology, vol. 132, no. 4, pp. 1196–1205, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Zen, M. Canova, C. Campana et al., “The kaleidoscope of glucorticoid effects on immune system,” Autoimmunity Reviews, vol. 10, no. 6, pp. 305–310, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. L. Iaccarino, A. Ghirardello, M. Canova et al., “Anti-annexins autoantibodies: their role as biomarkers of autoimmune diseases,” Autoimmunity Reviews, vol. 10, no. 9, pp. 553–558, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. B. Ranque and L. Mouthon, “Geoepidemiology of systemic sclerosis,” Autoimmunity Reviews, vol. 9, no. 5, pp. A311–A318, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. G. J. Tobón, P. Youinou, and A. Saraux, “The environment, geo-epidemiology, and autoimmune disease: rheumatoid arthritis,” Autoimmunity Reviews, vol. 9, no. 5, pp. A288–A292, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. A. T. Borchers, S. M. Naguwa, Y. Shoenfeld, and M. E. Gershwin, “The geoepidemiology of systemic lupus erythematosus,” Autoimmunity Reviews, vol. 9, no. 5, pp. A277–A287, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. C. Selmi and K. Tsuneyama, “Nutrition, geoepidemiology, and autoimmunity,” Autoimmunity Reviews, vol. 9, no. 5, pp. A267–A270, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. C. Selmi, “Autoimmunity in 2010,” Autoimmunity Reviews, vol. 10, no. 12, pp. 725–732, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. A. H. Auchincloss, A. V. Diez Roux, J. T. Dvonch et al., “Associations between recent exposure to ambient fine particulate matter and blood pressure in the multi-ethnic study of atherosclerosis (MESA),” Environmental Health Perspectives, vol. 116, no. 4, pp. 486–491, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. B. Ostro, M. Lipsett, P. Reynolds et al., “Long-term exposure to constituents of fine particulate air pollution and mortality: results from the California teachers study,” Environmental Health Perspectives, vol. 118, no. 3, pp. 363–369, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. O. Raaschou-Nielsen, Z. J. Andersen, M. Hvidberg et al., “Lung cancer incidence and long-term exposure to air pollution from traffic,” Environmental Health Perspectives, vol. 119, no. 6, pp. 860–865, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. A. S. Shah, J. P. Langrish, H. Nair et al., “Global association of air pollution and heart failure: a systematic review and meta-analysis,” The Lancet, vol. 21, no. 9897, pp. 1039–1048, 2013. View at Publisher · View at Google Scholar · View at Scopus
  41. N. Aden, A. Nuttall, X. Shiwen et al., “Epithelial cells promote fibroblast activation via IL-1α in systemic sclerosis,” Journal of Investigative Dermatology, vol. 130, no. 9, pp. 2191–2200, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. C. A. Feghali, K. L. Bost, D. W. Boulware, and L. S. Levy, “Mechanisms of pathogenesis in scleroderma. I. Overproduction of interleukin 6 by fibroblasts cultured from affected skin sites of patients with scleroderma,” The Journal of Rheumatology, vol. 19, no. 8, pp. 1207–1211, 1992. View at Google Scholar · View at Scopus
  43. M. Hasegawa, M. Fujimoto, T. Matsushita, Y. Hamaguchi, K. Takehara, and S. Sato, “Serum chemokine and cytokine levels as indicators of disease activity in patients with systemic sclerosis,” Clinical Rheumatology, vol. 30, no. 2, pp. 231–237, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. K. Khan, S. Xu, S. Nihtyanova et al., “Clinical and pathological significance of interleukin 6 overexpression in systemic sclerosis,” Annals of the Rheumatic Diseases, vol. 71, no. 7, pp. 1235–1242, 2012. View at Publisher · View at Google Scholar · View at Scopus
  45. W. U. Kim, S. Y. Min, M. L. Cho et al., “Elevated matrix metalloproteinase-9 in patients with systemic sclerosis,” Arthritis Research & Therapy, vol. 7, no. 1, pp. R71–R79, 2005. View at Google Scholar · View at Scopus
  46. M. Manetti, S. Guiducci, E. Romano et al., “Increased serum levels and tissue expression of matrix metalloproteinase-12 in patients with systemic sclerosis: correlation with severity of skin and pulmonary fibrosis and vascular damage,” Annals of the Rheumatic Diseases, vol. 71, no. 6, pp. 1064–1072, 2012. View at Publisher · View at Google Scholar · View at Scopus
  47. M. Verslegers, K. Lemmens, I. van Hove, and L. Moons, “Matrix metalloproteinase-2 and -9 as promising benefactors in development, plasticity and repair of the nervous system,” Progress in Neurobiology, vol. 105, pp. 60–78, 2013. View at Publisher · View at Google Scholar · View at Scopus
  48. W. J. Peng, J. W. Yan, Y. N. Wan et al., “Matrix metalloproteinases: a review of their structure and role in systemic sclerosis,” Journal of Clinical Immunology, vol. 32, no. 6, pp. 1409–1414, 2012. View at Publisher · View at Google Scholar · View at Scopus
  49. G. Sawicki, “Intracellular regulation of matrix metalloproteinase-2 activity: new strategies in treatment and protection of heart subjected to oxidative stress,” Scientifica, vol. 2013, Article ID 130451, 12 pages, 2013. View at Publisher · View at Google Scholar
  50. P. Moinzadeh, T. Krieg, M. Hellmich et al., “Elevated MMP-7 levels in patients with systemic sclerosis: correlation with pulmonary involvement,” Experimental Dermatology, vol. 20, no. 9, pp. 770–773, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. E. C. LeRoy, “Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast,” Journal of Clinical Investigation, vol. 54, no. 4, pp. 880–889, 1974. View at Google Scholar · View at Scopus
  52. J. Uitto, E. A. Bauer, and A. Z. Eisen, “Scleroderma: increased biosynthesis of triple-helical type I and type III procollagens associated with unaltered expression of collagenase by skin fibroblasts in culture,” Journal of Clinical Investigation, vol. 64, no. 4, pp. 921–930, 1979. View at Google Scholar · View at Scopus
  53. J. Peltonen, L. Kahari, J. Uitto, and S. A. Jimenez, “Increased expression of type VI collagen genes in systemic sclerosis,” Arthritis and Rheumatism, vol. 33, no. 12, pp. 1829–1835, 1990. View at Publisher · View at Google Scholar · View at Scopus
  54. K. Kuroda and H. Shinkai, “Gene expression of types I and III collagen, decorin, matrix metalloproteinases and tissue inhibitors of metalloproteinases in skin fibroblasts from patients with systemic sclerosis,” Archives of Dermatological Research, vol. 289, no. 10, pp. 567–572, 1997. View at Publisher · View at Google Scholar · View at Scopus