Antiphospholipase A2 Receptor Autoantibodies: A Comparison of Three Different Immunoassays for the Diagnosis of Idiopathic Membranous Nephropathy
Figure 2
Comparative receiver operating characteristic (ROC) analysis (CBA-IFA positive versus negative samples). The ALBIA and the EUROIMMUN ELISA were compared to the EUROIMMUN CBA-IFA. The EUROIMMUN CBA-IFA was the first commercially available immunoassay for anti-PLA2R and therefore was used to define the outcome (anti-PLA2R positive versus anti-PLA2R negative). With an area under the curve (AUC) of 0.99 (95% CI: 0.99 to 1.00), the ALBIA performed similar to the CBA-IFA assay. The ELISA reached an AUC of 0.94 (95% CI: 0.91 to 0.97). Cut-off values are indicated by the arrows. The ELISA was also analyzed with an alternative (borderline) cut-off of 14 units.
