Regulatory Lymphocytes Are Key Factors in MHC-Independent Resistance to EAE
Figure 1
Proliferative capacity of splenocytes from C57BL/6 (susceptible strain) and CD1 (resistant strain) mice. We analyzed proliferative capacity in series of seven mice per condition. Splenocytes from resistant and susceptible mice were stimulated with a polyclonal stimulus (PHA), MOG35–55, or PLP139–151. Susceptible mice showed a higher proliferative capacity upon PHA stimulation and a statistically significant augmented proliferation upon MOG stimulation. Conversely, splenocytes from both strains did not proliferate when the stimulus used was 139–151 PLP peptide.
