Regulatory Lymphocytes Are Key Factors in MHC-Independent Resistance to EAE

Table 1

Titers of anti-MOG serum antibodies and T cell and B cell percentages in spleen of mice resistant (CD1) and susceptible (C57BL/6) to MOG_35--55 induced EAE.

	Nonimmunized			MOG35--55-immunized			PLP139--151-immunized
	C57BL/6	CD1	𝑃	C57BL/6	CD1	𝑃	C57BL/6	CD1	𝑃
MOG-IgG (OD492 nm)	0.24±0.02	0.17±0.07	0.59	0.12±0.03	0.16±0.03	0.34	0.27±0.07	0.07±0.03	0.11
MOG-IgM (OD492 nm)	0.15±0.03	0.06±0.04	0.10	0.12±0.07	0.05±0.02	0.62	0.04±0.01	0.06±0.03	0.47
% CD4+ T cells	17.8±0.96	13.5±1.63	0.11	17.04±3.22	12.8±3.12	0.48	19.8±3.33	11.5±1.79	0.11
% CD8+ T cells	27.4±1.53	20.3±2.78	0.11	28.0±3.30	24.3±1.69	0.34	21.5±1.02	18.0±3.34	0.34

We studied nonimmunized mice and mice immunized with MOG_35--55 and PLP_139--151. We used eight animals per condition. Values are expressed as mean ± standard error. No differences were found in the levels of IgM or IgG anti-MOG_35--55 antibodies expressed as optical density at 492 nm, in the percentages of CD4+ and CD8+ T lymphocytes, and total B cells (B220+) between the different experimental groups.