Association of TNF-α with Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus

Figure 2

Association of elevated serum TNF-α with impaired migration of SLE BMSCs. (a) TNF-α blockers restored the decreased SLE BMSCs migration capacity induced by SLE serum (). (b) Serum level of TNF-α was significantly elevated in SLE patients compared to that of healthy controls. (c) TNF-α significantly decreased migration capacity of SLE BMSCs both in the wound healing () and transwell migration assays (). (d) TNF-α at either 50 μg/L or 100 μg/L had no impact on the proliferation rate of BMSCs from both healthy controls and SLE patients. TNF50: TNF-α: 50 μg/L; TNF100: TNF-α: 100 μg/L. ; .

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