Association of TNF-α with Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus

Figure 3

TNF-α decreased migration and in vivo homing capacity of SLE BMSCs via TNFRI. (a) TNFRI percentage was increased in SLE BMSCs (). (b) Ablation of TNFRI significantly converted TNF-α induced impaired migration capacity SLE BMSCs. (c) Compared with PBS treated SLE BMSCs group, in vivo homing capacity of TNF-α (50 μg/L) pretreated SLE BMSCs was markedly impaired, and preincubation of BMSCs with TNF-α together with TNFRI mAb instead of TNFRII mAb converted SLE BMSCs homing capacity with more SLE BMSCs homing for kidney, lymph node, and spleen. TNF50: TNF-α: 50 μg/L; TNF100: TNF-α: 100 μg/L. ; .

(a)

(b)

(c)