Association of TNF-α with Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus

Figure 4

Effect of IKK-β in impaired migration capacity of SLE BMSCs. (a) No difference was observed in IKK-β mRNA level between SLE patients and normal controls. (b) Phosphorylated-IKK-β protein expression of SLE BMSCs (1.38 ± 0.12) was significantly increased. (c) TPCA-1, a selective inhibitor of IKK-β, significantly increased the migration rate of SLE BMSCs both in the wound healing () and transwell migration assays. ; .

(a)

(b)

(c)