Association of TNF-α with Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus

Figure 5

Upregulation of p-IKK-β involved in TNF-α induced abnormal migration of SLE BMSCs. (a) Protein levels of p-IKK-β and t-IKK-β in SLE BMSCs after TPCA-1 or TNF-α treatment. (b) TPCA-1 could reverse the effect of TNF-α on migration capacity of SLE BMSCs in the wound healing and transwell migration assays (). TNF50: TNF-α: 50 μg/L; TNF100: TNF-α: 100 μg/L. .

(a)

(b)