Adoptive TIL Transfer in the Adjuvant Setting for Melanoma: Long-Term Patient Survival
Table 3
(a) Cox model for the relapse-free survival adjusted on prognosis factors. (b) Cox model for the overvall survival adjusted on prognosis factors.
(a)
IC 95% lower
OR
IC 95% upper
value
TIL + IL-2
0.121
0.297
0.731
0.0082
Lymph nodes > 1
0.506
0.971
1.865
0.930
Breslow > 1.5
1.242
2.477
4.943
0.0100
Capsular effraction
0.973
1.571
2.535
0.0654
TIL + IL-2 * lymph nodes > 1
1.732
5.087
14.945
0.0031
The Cox model showed a significant treatment effect () and confirmed the significant interaction between TIL + IL-2 and the number of invaded lymph nodes.
(b)
IC 95% lower
OR
IC 95% upper
value
TIL + IL2
0.117
0.305
0.794
0.0151
Lymph nodes > 1
0.419
0.8281
1.634
0.586
Breslow > 1.5
1.010
2.025
4.067
0.0471
Capsular effraction
1.239
2.085
3.508
0.0056
TIL + IL-2 * lymph nodes > 1
1.604
5.019
15.704
0.0057
The Cox model for the overall survival was comparable with that of the relapse-free survival.
