Osteodifferentiated Mesenchymal Stem Cells from Bone Marrow and Adipose Tissue Express HLA-G and Display Immunomodulatory Properties in HLA-Mismatched Settings: Implications in Bone Repair Therapy

<table>Both BM- andAT-derived MSCs when combined to MBCP biomaterial keep their hypoimmunogenicity. PBMC from healthy individual (#713) were used as responder cells towards either BM-derived MSCs (MSC-BM) or AT-derived MSCs (MSC-AT) that were pretreated with IFN<i><i>γ</i></i> and TNF<i><i>α</i></i> (IFN<i><i>γ</i></i>/TNF<i><i>α</i></i>) or not and used as stimulating cells at the responder : stimulator ratio of 1 : 0.2. MSCs were combined to MBCP biomaterial (MBCP) or not (No MBCP). Irradiated <svg height="14" id="M61" style="vertical-align:-0.17554pt" version="1.1" viewbox="0 0 37.1875 14" width="37.1875" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> were used as positive control of T cell alloproliferation. Results are given as mean cpm ± s.e.m.; one representative experiment is shown.</table>

Journal of Immunology Research

fig5

Figure 5

Figure 5: Osteodifferentiated Mesenchymal Stem Cells from Bone Marrow and Adipose Tissue Express HLA-G and Display Immunomodulatory Properties in HLA-Mismatched Settings: Implications in Bone Repair Therapy 

Figure 5 | Osteodifferentiated Mesenchymal Stem Cells from Bone Marrow and Adipose Tissue Express HLA-G and Display Immunomodulatory Properties in HLA-Mismatched Settings: Implications in Bone Repair Therapy 