Table of Contents Author Guidelines Submit a Manuscript
Journal of Immunology Research
Volume 2014, Article ID 240453, 10 pages
http://dx.doi.org/10.1155/2014/240453
Research Article

Long-Lasting Production of New T and B Cells and T-Cell Repertoire Diversity in Patients with Primary Immunodeficiency Who Had Undergone Stem Cell Transplantation: A Single-Centre Experience

1CREA, Diagnostics Department, Spedali Civili of Brescia, 25123 Brescia, Italy
2Department of Pediatric Oncohaematology and Bone Marrow Transplantation, Spedali Civili of Brescia, 25123 Brescia, Italy

Received 30 May 2014; Revised 13 August 2014; Accepted 8 September 2014; Published 1 December 2014

Academic Editor: Jolan Walter

Copyright © 2014 Monica Valotti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1: Histograms reporting the frequency distributions of: A) the number of samples per patient; B) samples belonging to transplanted and non transplanted patients in each age-class; C) patients in the time-classes corresponding to the first and last sampling; C) patients with a follow-up duration comprised into each time-class.

Supplementary Figure 2: Adjusted predicted probabilities of having KRECs over the cut-off, TRECs over the cut-off, an unrestricted repertoire calculated at several representative time-points (corresponding approximately to those depicted in Fig. 1 and 2) in HSCT-SCID vs HSCT-PID patients. Error bars represent the 95% confidence interval.

Supplementary Figure 3: Adjusted predicted probabilities of having KRECs over the cut-off, TRECs over the cut-off, an unrestricted repertoire at several representative time-points (corresponding approximately to those depicted in Fig. 1 and 2) in HSCT vs No-HSCT-PID patients. Error bars represent the 95% confidence interval.

Supplementary Figure 4: Adjusted predicted probabilities of having an unrestricted repertoire according to the model #2 reported in Table 4, to show the variable effects of GvHD and ablative conditioning during the follow-up. Probabilities were calculated at representative time-points showing the variable patterns of change over time. Error bars represent the 95% confidence interval.

  1. Supplementary Figures