Long-Lasting Production of New T and B Cells and T-Cell Repertoire Diversity in Patients with Primary Immunodeficiency Who Had Undergone Stem Cell Transplantation: A Single-Centre Experience

Table 2

Multivariable logistic models investigating differences in immune reconstitution between HSCT-SCID and -PID patients.

Outcome and contributing factors	OR	SE
Probability of having KRECs over the cut-off
PID	1	—	—
SCID	0.2300	0.2421	0.1630
Age at transplantation	1.0150	0.0178	0.3940
Time^a	1.0738	0.0167	0.0000
Time × time^b	0.9998	0.0001	0.0000
Probability of having TRECs over the cut-off
PID	1	—	—
SCID	0.4842	0.3562	0.3240
Age at transplantation	0.9942	0.0129	0.6550
Time	1.0420	0.0083	0.0000
Time × time^b	0.9997	0.0000	0.0000
Probability of having an unrestricted repertoire
PID	1	—	—
SCID	0.5076	0.1982	0.0820
Age at transplantation	0.9940	0.0069	0.3870
Time	1.0313	0.0058	0.0000
Time × time^b	0.9999	0.0000	0.0000

OR: odds ratio; SE: standard error.
HSCT: hematopoietic stem cell transplantation; KRECs: K-deleting recombination excision circles; PID: primary immunodeficiency; SCID: severe combined immunodeficiency; TRECs: T-cell receptor excision circles.
^aTime in months since transplantation; it represents the slope of the regression line (see Supplementary Figure  2); ^bthis factor represents the quadratic term needed to model the curved shape of time patterns, that is, the average monthly rate of change of the slope of the regression line.