Long-Lasting Production of New T and B Cells and T-Cell Repertoire Diversity in Patients with Primary Immunodeficiency Who Had Undergone Stem Cell Transplantation: A Single-Centre Experience

Table 3

Multivariable logistic models investigating differences in immune reconstitution between HSCT and no-HSCT patients.

Outcome and contributing factors	OR	SE
Probability of having KRECs over the cut-off
No-HSCT	1	—	—
HSCT	0.0111	0.0251	0.0470
Time^a	0.9879	0.0276	0.6640
Time × time^b	1.0001	0.0001	0.5150
HSCT × time	1.1002	0.0377	0.0050
HSCT × time × time^c	0.9997	0.0001	0.0060
Probability of having TRECs over the cut-off
No-HSCT	1	—	—
HSCT	0.2980	0.4389	0.4110
Time	0.9775	0.0209	0.2870
Time × time^b	0.9999	0.0001	0.5120
HSCT × time	1.0608	0.0246	0.0110
HSCT × time × time^c	0.9998	0.0001	0.0770
Probability of having an unrestricted repertoire
No-HSCT	1	—	—
HSCT	3.3335	1.6877	0.0170
Time^a	1.0231	0.0056	0.0000
Time × time^b	0.9999	0.0000	0.0190
HSCT × time	n/i	—	—
HSCT × time × time^c	n/i	—	—

OR: odds ratio; SE: standard error.
HSCT: hematopoietic stem cell transplantation; KRECs: K-deleting recombination excision circles; TRECs: T-cell receptor excision circles.
n/i: term not included in the model.
^aAge in months at the moment of sampling; it represents the slope of the regression line (see Supplementary Figure  3); ^bthis interaction represents the quadratic term needed to model the curved shape of time patterns, that is, the average monthly rate of change of the slope of the regression line. ^cThis interaction term represents the effect of HSCT on the rate of change of the slope.