Journal of Immunology Research / 2014 / Article / Tab 3

Research Article

Long-Lasting Production of New T and B Cells and T-Cell Repertoire Diversity in Patients with Primary Immunodeficiency Who Had Undergone Stem Cell Transplantation: A Single-Centre Experience

Table 3

Multivariable logistic models investigating differences in immune reconstitution between HSCT and no-HSCT patients.

Outcome and contributing factorsORSE

Probability of having KRECs over the cut-off
 No-HSCT1
 HSCT0.01110.02510.0470
 Timea0.98790.02760.6640
 Time × timeb1.00010.00010.5150
 HSCT × time1.10020.03770.0050
 HSCT × time × timec0.99970.00010.0060
Probability of having TRECs over the cut-off
 No-HSCT1
 HSCT0.29800.43890.4110
 Time0.97750.02090.2870
 Time × timeb0.99990.00010.5120
 HSCT × time1.06080.02460.0110
 HSCT × time × timec0.99980.00010.0770
Probability of having an unrestricted repertoire 
 No-HSCT1
 HSCT3.33351.68770.0170
 Timea1.02310.00560.0000
 Time × timeb0.99990.00000.0190
 HSCT × timen/i
 HSCT × time × timecn/i

OR: odds ratio; SE: standard error.
HSCT: hematopoietic stem cell transplantation; KRECs: K-deleting recombination excision circles; TRECs: T-cell receptor excision circles.
n/i: term not included in the model.
aAge in months at the moment of sampling; it represents the slope of the regression line (see Supplementary Figure  3); bthis interaction represents the quadratic term needed to model the curved shape of time patterns, that is, the average monthly rate of change of the slope of the regression line. cThis interaction term represents the effect of HSCT on the rate of change of the slope.

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