Soluble HLA Technology as a Strategy to Evaluate the Impact of HLA Mismatches

Figure 1

Assessment of targetable allogeneic epitopes. Every ligand has to pass several filters, before being presented in an HLA molecule. The first is the individual expression profile. Proteins then undergo further proteasomal processing, where the individual cleavage profile determines the sequence of possible HLA ligands. The last filter is the individual HLA profile that differs between allelic variants.