Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma
Table 1
Clinical correlation of YAP expression in HCC.
Clinicopathologic features
Total number of patients, =
YAP expression
−
+
Age (mean ± SD), years
39 ()
<55
23
6
17
0577
0.498
≥55
16
6
10
Sex
Men
35
10
25
0.774
0.573
Women
4
2
2
Tumor size, cm
>5
20
5
15
0.641
0.501
≤5
19
7
12
Edmonson grade
I+II
26
11
15
4.875
III
13
1
12
Venous infiltration
Present
6
3
3
1.231
0.348
Absent
33
9
24
Hepatitis
Negative
9
5
4
3.374
0.102
HBV/HCV
30
7
23
Serum AFP level, ng/mL
≤200
21
10
11
6.064
>200
18
2
16
TNM stage
I + II
15
5
10
0.075
1.000
III + IV
24
7
17
Number of tumor nodules
1
36
10
26
1.966
0.219
≥2
3
2
1
YAP indicates yes-associated protein; HCC: hepatocellular carcinoma; SD: standard deviation; HBV: hepatitis B virus; HCV: hepatitis C virus; AFP: -fetoprotein; TNM: tumor node metastasis. Tumor size was measured by the length of the largest tumor nodule. Statistically significant.
