Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma
Table 2
Clinical correlation of AREG expression in HCC.
Clinicopathologic features
Total number of patients, =
AREG expression
−
+
Age (mean ± SD), years
39 ()
<55
23
8
15
0.321
0.740
≥55
16
7
9
Sex
Men
35
13
22
0.251
0.631
Women
4
2
2
Tumor size, cm
>5
20
9
11
0.742
0.514
≤5
19
6
13
Edmonson grade
I + II
26
5
21
12.188
III
13
10
3
Venous infiltration
Present
6
3
3
0.399
0.658
Absent
33
12
21
Hepatitis
Negative
9
4
5
0.177
0.711
HBV/HCV
30
11
19
Serum AFP level, ng/mL
≤200
21
3
18
11.236
>200
18
12
6
TNM stage
I + II
15
6
9
0.024
1.000
III + IV
24
9
15
Number of tumor nodules
1
36
13
23
1.092
0.547
≥2
3
2
1
AREG indicates amphiregulin protein; HCC: hepatocellular carcinoma; SD: standard deviation; HBV: hepatitis B virus; HCV: hepatitis C virus; AFP: -fetoprotein; TNM: tumor node metastasis. Tumor size was measured by the length of the largest tumor nodule. Statistically significant.
