Clinical Study

Fcγ-Receptor IIIA Polymorphism p.158F Has No Negative Predictive Impact on Rituximab Therapy with and without Sequential Chemotherapy in CD20-Positive Posttransplant Lymphoproliferative Disorder

Table 4

Treatment response by FcγRIIIA polymorphism p.V158F: non-F-carrier versus F carrier.

Patients in trialFcγRIIIA p.158 evaluatedFcγRIIIA p.158 non-F-carrierFcγRIIIA p.158 F carrier

Response to 4 cycles rituximab (PT-LPD1 and PTLD-1 interim staging combined)
Number of patients87251114
ORR17/258/119/140.65
CR 11/25 6/11 5/14 0.35
PR 6/25 2/11 4/14 0.55

ORR denotes overall response rate, CR: complete remission, PR: partial remission, SD: stable disease, and PD: progressive disease. *Missing patients could not be evaluated for response due to early death.