HLA-G Expression Is an Independent Predictor for Improved Survival in High Grade Ovarian Carcinomas

Table 3

Cox regression analysis on disease specific survival including clinicopathological factors and HLA expression.

Disease specific survival	Univariable analysis			Multivariable analysis
	HR	95% CI	𝑃 value	HR	95% CI	𝑃 value
Age (years)	1.01	0.99–1.03	0.185
FIGO stage
Low (I-IIA)	1			1
High (IIB–IV)	4.70	1.16–19.17	0.030	3.74	0.48–28.99	0.207
Kind of surgery
PDS	1			1
IDS	1.80	1.15–2.91	0.011	2.48	1.49–4.15	0.001
Residual disease
Microscopic	1			1
Macroscopic	2.60	1.57–4.43	<0.000	2.21	1.21–4.02	0.009
HLA-A expression
Normal	1
Downregulation	1.30	0.85–1.98	0.231
HLA-B/C expression
Normal	1
Downregulation	1.13	0.68–1.88	0.647
HLA-E expression
Normal	1
Upregulation	1.31	0.75–2.27	0.341
HLA-G Expression
Normal	1.69	1.14–2.51	0.009	1.62	1.08–2.42	0.020
Upregulation	1

HR: hazards ratio, CI: confidence interval, Ref.: referent, PDS: primary debulking surgery, IDS: interval debulking surgery.