Research Article
Polymorphisms of Tumor Necrosis Factor-α, Transforming Growth Factor-β, and Interleukin-10 in Asthma Associated with Olive Pollen Sensitization
Table 3
TNF-
, IL-10, and TGF-
genotype and allele frequencies.
| |
Polymorphism |
Genotypes and alleles | Patients
( = 146) | Controls
( = 50) | Asthma
( = 109) | Rhinitis
( = 37) | value | | (%) | (%) | (%) | (%) | Controls versus patients | Asthma versus rhinitis |
| | TNFA-308G>A | GG | 116 (79.4) | 40 (80) | 85 (78) | 31 (83.8) | ns | ns | | GA | 28 (19.2) | 9 (18) | 22 (20.2) | 6 (16.2) | ns | ns | | AA | 2 (1.4) | 1 (2) | 2 (1.8) | 0 | ns | ns | | G | 260 (89%) | 89 (89%) | 192 (88%) | 68 (91.8%) | ns | ns | | A | 32 (11%) | 11 (11%) | 26 (12%) | 6 (8.2%) | ns | ns |
| | TNFA-857C>T | CC | 122 (83.6) | 44 (88) | 92 (84.4) | 30 (81.1) | ns | ns | | CT | 21 (14.4) | 6 (12) | 15 (13.8) | 6 (16.2) | ns | ns | | TT | 3 (2) | 0 | 2 (1.8) | 1 (2.7) | ns | ns | | C | 265 (90.7%) | 94 (94%) | 199 (91.2%) | 66 (89.2) | ns | ns | | T | 27 (9.3%) |
6 (6%) |
19 (8.8%) | 8 (10.8) | ns | ns |
| | TNFA-1031C>T | CC | 7 (4.8) | 6 (12) | 6 (5.5) | 1 (2.7) | ns | ns | | CT | 59 (40.4) | 21 (42) | 44 (40.4) | 15 (40.5) | ns | ns | | TT | 80 (54.8) | 23 (46) | 59 (54.1) | 21 (56.8) | ns | ns | | C | 73 (25%) | 33 (33%) | 56 (25.6%) | 17 (23%) | ns | ns | | T | 219 (75%) | 67 (67%) | 162 (74.4%) | 57 (77%) | ns | ns |
| | IL-10-571C>A | CC | 82 (56.2) | 27 (54) | 62 (56.8) | 20 (54.1) | ns | ns | | CA | 58 (39.7) | 18 (36) | 43 (39.4) | 15 (40.5) | ns | ns | | AA | 6 (4.1) | 5 (10) | 4 (3.6) | 2 (5.41) | ns | ns | | C | 222 (76%) | 72 (72%) | 167 (76.6%) | 55 (74.3%) | ns | ns | | A | 70 (24%) | 28 (28%) | 51 (23.4%) | 19 (25.7%) | ns | ns |
| | IL-10-1117A>G | AA | 49 (33.5) | 21 (42) | 39 (35.7) | 10 (27) | ns | ns | | AG | 62 (42.4) | 22 (44) | 42 (38.5) | 20 (54) | ns | ns | | GG | 35 (23.9) | 7 (14) | 28 (25.6) | 7 (18.9) | ns | ns | | A | 160 (54.8%) | 64 (64%) | 120 (55%) | 40 (54%) | ns | ns | | G | 132 (45.2%) | 36 (36%) | 98 (45%) | 34 (46%) | ns | ns |
| | TGF-β-C-509-T | CC | 56 (38.3) | 26 (52) | 44 (40.4) | 12 (32.4) | ns | ns | | CT | 83 (56.8) | 20 (40) | 60 (55) | 23 (62.1) | = 0.039
0R = 1.97
(95% CI 1.02–3.8) | ns | | TT | 7 (4.7) | 4 (8) | 5 (4.6) | 2 (5.4) | ns | ns | | C | 195 (66.7%) | 72 (72%) | 148 (67.8%) | 47 (63.5%) | ns | ns | | T | 97 (33.3%) | 28 (28%) | 70 (32.2%) | 27 (36.5%) | ns | ns |
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