Appropriate Development of the Liver Treg Compartment Is Modulated by the Microbiota and Requires TGF-β and MyD88

Figure 2

Postnatal development of FoxP3⁺CD4⁺ cells in thymus, spleen, and liver. NPC were isolated from thymus, spleen, and liver of BALB/c-background transgenic reporter mice of the indicated ages. (a) Individual GFP expression profiles of CD4⁺ T cells are shown. (b) Composite data from several mice are shown. Frequency indicates the percentage of CD4⁺ T cells that coexpress eGFP as a reporter of FoxP3 expression. to 8 mice per time point. (c) Composite data from several mice are shown. Density indicates the number of CD4⁺eGFP⁺ cells per wet weight of the organ. to 8 mice per time point.

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